Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …

Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

We have designed a highly specific inhibitor of calpain by mimicking a natural protein–
protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this …

Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-
dependent cysteine protease core. These are not degradative enzymes, but instead carry …

The excessive extracellular accumulation of glutamate in the ischemic brain leads to an
overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal …

Cataracts are one of the most prevalent diseases of the lens, affecting its transparency and
are the leading cause of reversible blindness in the world. The clarity of the lens is essential …

Introduction: Calpain is a cysteine protease that participates in normal signal transduction
events, but deregulation of its action may result in pathologies such as neurological …

A new highly enantioselective route to α-alkenyl α-amino acid derivatives, which are
important naturally occurring compounds with attractive bioactivity and synthetic utility, was …

Many natural products consist of large and flexible macrocycles that engage their targets via
multiple contact points. This combination of contained flexibility and large contact area often …