Ohwia caudata aqueous extract attenuates senescence in aging adipose-derived mesenchymal stem cells

TJ Ho, BCK Tsai, G Debakshee, MA Shibu, CH Kuo… - Heliyon, 2024 - cell.com
Stem cells exhibit pluripotency and self-renewal abilities. Adipose-derived 59 mesenchymal
stem cells can potentially be used to reconstruct various tissues. They 60 possess significant …

Enhanced IGF‐IIRα Expression Exacerbates Lipopolysaccharide‐Induced Cardiac Inflammation, Hypertrophy, and Apoptosis Through Calcineurin Activation

K Boonha, WW Kuo, BCK Tsai… - Environmental …, 2024 - Wiley Online Library
Cardiovascular disease is one of the leading causes of death worldwide and has a high
prevalence. Insulin‐like growth factor‐II receptor α (IGF‐IIRα) acts as a stress‐inducible …

Calycosin Enhances Heat Shock Related-Proteins in H9c2 Cells to Modulate Survival and Apoptosis against Heat Shock

PF Lai, R Mahendran, BCK Tsai, CY Lu… - The American journal …, 2024 - World Scientific
Heat shock proteins (HSPs), which function as chaperones, are activated in response to
various environmental stressors. In addition to their role in diverse aspects of protein …

Rhodiola and Salidroside Attenuate Oxidative Stress‐Triggered H9c2 Cardiomyoblast Apoptosis Through IGF1R‐Induced ERK1/2 Activation

IJ Ju, BCK Tsai, WW Kuo, CH Kuo… - Environmental …, 2024 - Wiley Online Library
Oxidative stress is a pivotal factor in the pathogenesis of various cardiovascular diseases.
Rhodiola, a traditional Chinese medicine, is recognized for its potent antioxidant properties …

Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

CC Li, BCK Tsai, S Annseles Rajula, CH Hsu… - Cell Biochemistry and …, 2024 - Springer
Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its
pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid …

Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging

SY Wen, SC Ng, L Noriega, TJ Chen, CJ Chen… - …, 2025 - Wiley Online Library
Ultraviolet (UV) irradiation is a major factor contributing to skin photoaging, including the
formation of reactive oxygen species (ROS), collagen breakdown, and overall skin damage …

**g‐Si Herbal Tea Suppresses H2O2 ‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes

SW Kao, YC Chang, FH Lin, TL Huang… - Environmental …, 2024 - Wiley Online Library
Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in
humans; however, its undesired activation results in tissue damage and cell death. The …

Low‐concentration imiquimod treatment promotes enhanced skin barrier functions through epidermal melanization reaction regulation

TK Lin, CL Tsai, BCK Tsai, CH Kuo… - Environmental …, 2024 - Wiley Online Library
The primary function of the skin is to form a mechanical, permeability, antimicrobial, and
ultraviolet radiation barrier, which is essential for maintaining physiological homeostasis …

Hepatocellular Carcinoma Cells in Humans Exhibit Resistance to Suberoylanilide Hydroxamic Acid (SAHA) Owing to the Diminished Level of Hsa‐miR‐125a‐5p

SW Kao, WW Kuo, BCK Tsai… - Chemical Biology & …, 2025 - Wiley Online Library
Hepatocellular carcinoma (HCC) presents an escalating public health challenge globally.
However, drug resistance has emerged as a major impediment to successful HCC …

Renal protective effects of Alpinate Oxyphyllae Fructus and mesenchymal stem cells co-treatment against D-galactose induced renal deterioration

TJ Ho, T Shanmugam, PH Liao… - … Journal of Medical …, 2024 - pmc.ncbi.nlm.nih.gov
Age-related structural and functional changes in the kidney can eventually lead to
development of chronic kidney disease, which is one of the leading causes of mortality …