Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

The PubMLST. org website hosts a collection of open-access, curated databases that
integrate population sequence data with provenance and phenotype information for over …

Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …

Genome-wide association studies (GWAS) have become indispensable in human medicine
and genomics, but very few have been carried out on bacteria. Here we introduce Scoary …

Genome-wide association studies (GWASs) have provided numerous associations between
human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome …

Analysis of “big data” frequently involves statistical comparison of millions of competing
hypotheses to discover hidden processes underlying observed patterns of data, for example …

To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …

We present fastbaps, a fast solution to the genetic clustering problem. Fastbaps rapidly
identifies an approximate fit to a Dirichlet process mixture model (DPM) for clustering …

Some bacteria can transfer to new host species, and this poses a risk to human health.
Indeed, an estimated 60% of all human pathogens have originated from other animal …