Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …
spaceflight biology that guide our current understanding of fundamental molecular changes …
Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
Apoptotic cell-derived extracellular vesicles promote malignancy of glioblastoma via intercellular transfer of splicing factors
Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells
adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic …
adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic …
Development and MPI tracking of novel hypoxia-targeted theranostic exosomes
Treating the hypoxic region of the tumor remains a significant challenge. The goals of this
study are to develop an exosome platform that can target regions of tumor hypoxia and that …
study are to develop an exosome platform that can target regions of tumor hypoxia and that …
Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation
A Abramowicz, P Widlak, M Pietrowska - Molecular BioSystems, 2016 - pubs.rsc.org
The re-discovery of exosomes as intercellular messengers with high potential for diagnostic
and therapeutic utility has led to them becoming a popular topic of research in recent years …
and therapeutic utility has led to them becoming a popular topic of research in recent years …
Low-dose non-targeted effects and mitochondrial control
D Averbeck - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …
Ionizing radiation increases the activity of exosomal secretory pathway in MCF-7 human breast cancer cells: a possible way to communicate resistance against …
Radiation therapy, which applies high-energy rays, to eradicate tumor cells, is considered
an essential therapy for the patients with breast cancer. Most tumor cells secrete exosomes …
an essential therapy for the patients with breast cancer. Most tumor cells secrete exosomes …
Role of extracellular vesicles (EVs) in cell stress response and resistance to cancer therapy
CP O'Neill, KE Gilligan, RM Dwyer - Cancers, 2019 - mdpi.com
Extracellular vesicles (EVs) are nanosized particles released by all cells that have been
heralded as novel regulators of cell-to-cell communication. It is becoming increasingly clear …
heralded as novel regulators of cell-to-cell communication. It is becoming increasingly clear …
Tumor-derived extracellular vesicles regulate cancer progression in the tumor microenvironment
Q Bao, Q Huang, Y Chen, Q Wang, R Sang… - Frontiers in molecular …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are nanosized particles released by numerous kinds of cells,
which are now increasingly considered as essential vehicles of cell-to-cell communication …
which are now increasingly considered as essential vehicles of cell-to-cell communication …
The emerging role of exosomes in diagnosis, prognosis, and therapy in head and neck cancer
Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA,
and lipids, which they efficiently deliver to recipient cells, generating a communication …
and lipids, which they efficiently deliver to recipient cells, generating a communication …