Census and evaluation of p53 target genes
M Fischer - Oncogene, 2017 - nature.com
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …
gene alters its response pathway, and is central to the development of many cancers. The …
Transgenic mouse models in cancer research
The use of existing mouse models in cancer research is of utmost importance as they aim to
explore the casual link between candidate cancer genes and carcinogenesis as well as to …
explore the casual link between candidate cancer genes and carcinogenesis as well as to …
Spontaneous and induced animal models for cancer research
Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …
models in biomedical research is critical in light of the capacity to produce valuable data with …
Improved survival analysis by learning shared genomic information from pan-cancer data
Motivation Recent advances in deep learning have offered solutions to many biomedical
tasks. However, there remains a challenge in applying deep learning to survival analysis …
tasks. However, there remains a challenge in applying deep learning to survival analysis …
N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation
T Zhao, D Sun, M Zhao, Y Lai, Y Liu, Z Zhang - Environmental Pollution, 2020 - Elsevier
Abstract N 6-methyladenosine (m 6 A), the most abundant and reversible RNA modification,
plays critical a role in tumorigenesis. However, whether m 6 A can regulate p53, a leading …
plays critical a role in tumorigenesis. However, whether m 6 A can regulate p53, a leading …
Novel potential inhibitors of complement system and their roles in complement regulation and beyond
The complement system resembles a double-edged sword since its activation can either
benefit or harm the host. Thus, regulation of this system is of utmost importance and …
benefit or harm the host. Thus, regulation of this system is of utmost importance and …
Stargardt phenotype associated with two ELOVL4 promoter variants and ELOVL4 downregulation: new possible perspective to etiopathogenesis?
L Donato, C Scimone, C Rinaldi… - … & visual science, 2018 - iovs.arvojournals.org
Purpose: Stargardt disease (STGD) is the most common form of inherited juvenile macular
degeneration. It is inherited as autosomal recessive trait (STGD1), although STGD3 and …
degeneration. It is inherited as autosomal recessive trait (STGD1), although STGD3 and …
Breathing new insights into the role of mutant p53 in lung cancer
The tumour suppressor gene p53 is one of the most frequently mutated genes in lung cancer
and these defects are associated with poor prognosis, albeit some debate exists in the lung …
and these defects are associated with poor prognosis, albeit some debate exists in the lung …
[HTML][HTML] Genome-wide association study of feed conversion ratio in turbot (Scophthalmus maximus) based on genome resequencing
Z Liu, H Chang, F Xu, H Zhao, L Zhu, Z Sun, M Yang… - Aquaculture …, 2023 - Elsevier
The feed conversion rate (FCR) is a crucial economic trait in aquaculture fish, as feed costs
account for the vast majority of aquaculture costs. Given the importance of this trait, there …
account for the vast majority of aquaculture costs. Given the importance of this trait, there …
KIAA 0247 inhibits growth, migration, invasion of non‐small‐cell lung cancer through regulating the Notch pathway
Y Xu, H Ren, J Jiang, Q Wang, M Wudu… - Cancer …, 2018 - Wiley Online Library
Lung cancer remains the leading cause of cancer‐related death worldwide. Previous
studies have shown that the novel KIAA 0247 gene potentially targeted by the tumor …
studies have shown that the novel KIAA 0247 gene potentially targeted by the tumor …