Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

Motivation A fundamental interest in chronobiology is to compare patterns between groups
of rhythmic data. However, many existing methods are ill-equipped to derive statements …

Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that
sustain rapid proliferation and metastasis. However, the mechanisms that control the …

Starting with the beginning of the last century, a multitude of scientific studies has
documented that the lunar cycle times behaviors and physiology in many organisms. It is …

Phase separation and biorhythms control biological processes in the spatial and temporal
dimensions, respectively, but mechanisms of four-dimensional integration remain elusive …

The Akt/mechanistic target of rapamycin (mTOR) signaling pathway governs macromolecule
synthesis, cell growth, and metabolism in response to nutrients and growth factors …

A distinct 12-hour clock exists in addition to the 24-hour circadian clock to coordinate
metabolic and stress rhythms. Here, we show that liver-specific ablation of X-box binding …

Our group recently characterized a cell-autonomous mammalian 12-h clock independent
from the circadian clock, but its function and mechanism of regulation remain poorly …