Introducing protein intrinsic disorder
Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
A review of methods available to estimate solvent-accessible surface areas of soluble proteins in the folded and unfolded states
Solvent accessible surface area (SASA) of proteins has always been considered as a
decisive factor in protein folding and stability studies. It is defined as the surface …
decisive factor in protein folding and stability studies. It is defined as the surface …
Structural characterization of flexible proteins using small-angle X-ray scattering
Structural analysis of flexible macromolecular systems such as intrinsically disordered or
multidomain proteins with flexible linkers is a difficult task as high-resolution techniques are …
multidomain proteins with flexible linkers is a difficult task as high-resolution techniques are …
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …
Advances in homology protein structure modeling
Z **ang - Current Protein and Peptide Science, 2006 - ingentaconnect.com
Homology modeling plays a central role in determining protein structure in the structural
genomics project. The importance of homology modeling has been steadily increasing …
genomics project. The importance of homology modeling has been steadily increasing …
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
M Wells, H Tidow, TJ Rutherford… - Proceedings of the …, 2008 - National Acad Sciences
Proteins with intrinsically disordered domains are implicated in a vast range of biological
processes, especially in cell signaling and regulation. Having solved the quaternary …
processes, especially in cell signaling and regulation. Having solved the quaternary …
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
Many cell signaling events are coordinated by intrinsically disordered protein regions (IDRs)
that undergo multisite Serine/Threonine phosphorylation. The conformational properties of …
that undergo multisite Serine/Threonine phosphorylation. The conformational properties of …
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering
Natively unfolded proteins play key roles in normal and pathological biochemical processes.
Despite their importance for function, this category of proteins remains beyond the reach of …
Despite their importance for function, this category of proteins remains beyond the reach of …
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
M Varadi, S Kosol, P Lebrun, E Valentini… - Nucleic acids …, 2014 - academic.oup.com
The goal of pE-DB (http://pedb. vib. be) is to serve as an openly accessible database for the
deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of …
deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of …
Protein-protein docking using region-based 3D Zernike descriptors
Background Protein-protein interactions are a pivotal component of many biological
processes and mediate a variety of functions. Knowing the tertiary structure of a protein …
processes and mediate a variety of functions. Knowing the tertiary structure of a protein …