From demyelination to remyelination: the road toward therapies for spinal cord injury
F Papastefanaki, R Matsas - Glia, 2015 - Wiley Online Library
Myelin integrity is crucial for central nervous system (CNS) physiology while its preservation
and regeneration after spinal cord injury (SCI) is key to functional restoration. Disturbance of …
and regeneration after spinal cord injury (SCI) is key to functional restoration. Disturbance of …
Small-molecule based musculoskeletal regenerative engineering
Clinicians and scientists working in the field of regenerative engineering are actively
investigating a wide range of methods to promote musculoskeletal tissue regeneration …
investigating a wide range of methods to promote musculoskeletal tissue regeneration …
Polycaprolactone/polysialic acid hybrid, multifunctional nanofiber scaffolds for treatment of spinal cord injury
S Zhang, XJ Wang, WS Li, XL Xu, JB Hu, XQ Kang, J Qi… - Acta biomaterialia, 2018 - Elsevier
Scaffold-based tissue engineering is widely used for spinal cord injury (SCI) treatment by
creating supporting and guiding neuronal tissue regeneration. However, how to enhance …
creating supporting and guiding neuronal tissue regeneration. However, how to enhance …
Biomaterial-based regenerative therapeutic strategies for spinal cord injury
K Chen, W Yu, G Zheng, Z Xu, C Yang, Y Wang… - NPG Asia …, 2024 - nature.com
As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to
permanent neurological impairment in patients. Unfortunately, due to the complex …
permanent neurological impairment in patients. Unfortunately, due to the complex …
Small molecule agonists of cell adhesion molecule L1 mimic L1 functions in vivo
Lack of permissive mechanisms and abundance of inhibitory molecules in the lesioned
central nervous system of adult mammals contribute to the failure of functional recovery after …
central nervous system of adult mammals contribute to the failure of functional recovery after …
Interactions of the mechanosensitive channels with extracellular matrix, integrins, and cytoskeletal network in osmosensation
R Jiao, D Cui, SC Wang, D Li, YF Wang - Frontiers in Molecular …, 2017 - frontiersin.org
Life is maintained in a sea water-like internal environment. The homeostasis of this
environment is dependent on osmosensory system translation of hydromineral information …
environment is dependent on osmosensory system translation of hydromineral information …
The neuroplasticity marker PSA-NCAM: Insights into new therapeutic avenues for promoting neuroregeneration
Neuroplastic alterations are the key processes involved in adaptation and rehabilitation after
all neurological injuries and pathologies. Being the central contributor to the developmental …
all neurological injuries and pathologies. Being the central contributor to the developmental …
The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease
S Chen, Q Jiang, P Huang, C Hu, H Shen… - Brain research …, 2020 - Elsevier
Alzheimer's disease (AD) is characterized by deposition of β-amyloid protein (Aβ),
neurofibrillary tangles and cognitive deficits resulting from neuronal cell death. In search for …
neurofibrillary tangles and cognitive deficits resulting from neuronal cell death. In search for …
The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair
Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell
adhesion molecule (NCAM). Several studies have shown that it is important for correct …
adhesion molecule (NCAM). Several studies have shown that it is important for correct …
Amelioration of the abnormal phenotype of a new L1 syndrome mouse mutation with L1 mimetics
G Loers, D Appel, D Lutz, L Congiu… - The FASEB …, 2021 - Wiley Online Library
L1 syndrome is a rare developmental disorder characterized by hydrocephalus of varying
severity, intellectual deficits, spasticity of the legs, and adducted thumbs. Therapy is limited …
severity, intellectual deficits, spasticity of the legs, and adducted thumbs. Therapy is limited …