[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …
Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates
O Goethals, SJF Kaptein, B Kesteleyn, JF Bonfanti… - Nature, 2023 - nature.com
Dengue is a major health threat and the number of symptomatic infections caused by the
four dengue serotypes is estimated to be 96 million with annually around 10,000 deaths …
four dengue serotypes is estimated to be 96 million with annually around 10,000 deaths …
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
SJF Kaptein, O Goethals, D Kiemel, A Marchand… - Nature, 2021 - nature.com
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting
as dengue fever or occasionally as severe dengue,. There are no antiviral agents available …
as dengue fever or occasionally as severe dengue,. There are no antiviral agents available …
Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses
With no antiviral drugs or widely available vaccines, Dengue virus (DENV) constitutes a
public health concern. DENV replicates at ER-derived cytoplasmic structures that include …
public health concern. DENV replicates at ER-derived cytoplasmic structures that include …
Dengue virus non-structural protein 1 modulates infectious particle production via interaction with the structural proteins
Non-structural protein 1 (NS1) is one of the most enigmatic proteins of the Dengue virus
(DENV), playing distinct functions in immune evasion, pathogenesis and viral replication …
(DENV), playing distinct functions in immune evasion, pathogenesis and viral replication …
Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation
Dengue fever represents a significant medical and socio-economic burden in (sub) tropical
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …
The multiples fates of the flavivirus RNA genome during pathogenesis
C Mazeaud, W Freppel, L Chatel-Chaix - Frontiers in genetics, 2018 - frontiersin.org
The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow
fever viruses) which constitute important public health concerns worldwide. For several of …
fever viruses) which constitute important public health concerns worldwide. For several of …
Molecular insights into the flavivirus replication complex
K Van den Elsen, JP Quek, D Luo - Viruses, 2021 - mdpi.com
Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …
[HTML][HTML] Dengue hemorrhagic fever and the liver
W Leowattana, T Leowattana - World journal of hepatology, 2021 - ncbi.nlm.nih.gov
Dengue hemorrhagic fever (DHF) is one of the most rapidly emerging infections of tropical
and subtropical regions worldwide. It affects more rural and urban areas due to many …
and subtropical regions worldwide. It affects more rural and urban areas due to many …