Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target
for human cancers and other human diseases. Herein, we report our discovery of potent …

Activating mutations in PTPN11, encoding the cytosolic protein tyrosine phosphatase SHP2,
result in developmental disorders and act as oncogenic drivers in patients with hematologic …

Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …

Phosphorylation as a post-translational modification is critical for cellular homeostasis.
Kinases and phosphatases regulate phosphorylation levels by adding or removing …