Microfluidics for sperm analysis and selection

R Nosrati, PJ Graham, B Zhang, J Riordon… - Nature Reviews …, 2017 - nature.com
Infertility is a growing global health issue with far-reaching socioeconomic implications. A
downward trend in male fertility highlights the acute need for affordable and accessible …

Machine learning for sperm selection

JB You, C McCallum, Y Wang, J Riordon… - Nature Reviews …, 2021 - nature.com
Infertility rates and the number of couples seeking fertility care have increased worldwide
over the past few decades. Over 2.5 million cycles of assisted reproductive technologies are …

Human sperm rheotaxis: a passive physical process

Z Zhang, J Liu, J Meriano, C Ru, S **e, J Luo, Y Sun - Scientific reports, 2016 - nature.com
A long-standing question in natural reproduction is how mammalian sperm navigate inside
female reproductive tract and finally reach the egg cell, or oocyte. Recently, fluid flow was …

Curvature in the reproductive tract alters sperm–surface interactions

MR Raveshi, MS Abdul Halim, SN Agnihotri… - Nature …, 2021 - nature.com
The fallopian tube is lined with a highly complex folded epithelium surrounding a lumen that
progressively narrows. To study the influence of this labyrinthine complexity on sperm …

Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system

M Zaferani, SH Cheong, A Abbaspourrad - Proceedings of the National …, 2018 - pnas.org
The separation of motile sperm from semen samples is sought after for medical infertility
treatments. In this work, we demonstrate a high-throughput microfluidic device that can …

Advances in sperm analysis: techniques, discoveries and applications

C Dai, Z Zhang, G Shan, LT Chu, Z Huang… - Nature Reviews …, 2021 - nature.com
Infertility affects one in six couples worldwide, and fertility continues to deteriorate globally,
partly owing to a decline in semen quality. Sperm analysis has a central role in diagnosing …

Human sperm ion channel (dys) function: implications for fertilization

SG Brown, SJ Publicover, CLR Barratt… - Human reproduction …, 2019 - academic.oup.com
BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

[HTML][HTML] Computer software (SiD) assisted real-time single sperm selection associated with fertilization and blastocyst formation

G Mendizabal-Ruiz, A Chavez-Badiola… - Reproductive …, 2022 - Elsevier
Research question: Using a novel artificial vision-based software (SiD V1. 0; IVF 2.0, UK),
we aimed to explore a correlation between individual sperm kinematics evaluated in real …

Live births from artificial insemination of microfluidic-sorted bovine spermatozoa characterized by trajectories correlated with fertility

MPB Nagata, K Endo, K Ogata, K Yamanaka… - Proceedings of the …, 2018 - pnas.org
Selection of functional spermatozoa plays a crucial role in assisted reproduction. Passage of
spermatozoa through the female reproductive tract requires progressive motility to locate the …