Chalcone: a privileged structure in medicinal chemistry

C Zhuang, W Zhang, C Sheng, W Zhang, C **ng… - Chemical …, 2017 - ACS Publications
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Review on the antibacterial mechanism of plant‐derived compounds against multidrug‐resistant bacteria (MDR)

N Jubair, M Rajagopal, S Chinnappan… - Evidence‐Based …, 2021 - Wiley Online Library
Microbial resistance has progressed rapidly and is becoming the leading cause of death
globally. The spread of antibiotic‐resistant microorganisms has been a significant threat to …

Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

A review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in Alzheimer disease

SC Peitzika, E Pontiki - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …

Molecular targets and anticancer activity of quinoline–chalcone hybrids: Literature review

MFA Mohamed, GEDA Abuo-Rahma - RSC advances, 2020 - pubs.rsc.org
α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials

Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Experimental and computational studies on second-and third-order nonlinear optical properties of a novel D-π-A type chalcone derivative: 3-(4-methoxyphenyl)-1-(4 …

SR Maidur, PS Patil, SV Rao, M Shkir… - Optics & Laser …, 2017 - Elsevier
The present study reports the theoretical and experimental investigations of linear and
nonlinear optical (static and dynamic) properties of 3-(4-methoxyphenyl)-1-(4-nitrophenyl) …

Review and chemoinformatic analysis of ferroptosis modulators with a focus on natural plant products

V Stepanić, M Kučerová-Chlupáčová - Molecules, 2023 - mdpi.com
Ferroptosis is a regular cell death pathway that has been proposed as a suitable therapeutic
target in cancer and neurodegenerative diseases. Since its definition in 2012, a few hundred …

A systematic review on anti-diabetic properties of chalcones

S Rocha, D Ribeiro, E Fernandes… - Current medicinal …, 2020 - ingentaconnect.com
The use of anti-diabetic drugs has been increasing worldwide and the evolution of
therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not …