Reactive oxygen species formation in the brain at different oxygen levels: the role of hypoxia inducible factors
Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …
Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
The ischemic environment drives microglia and macrophage function
Cells of myeloid origin, such as microglia and macrophages, act at the crossroads of several
inflammatory mechanisms during pathophysiology. Besides pro-inflammatory activity (M1 …
inflammatory mechanisms during pathophysiology. Besides pro-inflammatory activity (M1 …
Hypoxia-inducible factor-1: Regulatory mechanisms and drug development in stroke
Z Pan, G Ma, L Kong, G Du - Pharmacological research, 2021 - Elsevier
Stroke is an acute cerebrovascular disease caused by sudden rupture of blood vessels in
the brain or blockage of blood vessels, which has now become one of the main causes of …
the brain or blockage of blood vessels, which has now become one of the main causes of …
Glial development: the crossroads of regeneration and repair in the CNS
Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …
regenerative medicine. Extraordinary efforts have been made to understand developmental …
Hypoxia-mediated drug resistance in breast cancers
CE McAleese, C Choudhury, NJ Butcher, RF Minchin - Cancer letters, 2021 - Elsevier
Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances …
tumor growth, including altered microvasculature structure, increased diffusional distances …
Heart failure and cognitive dysfunction
J Ampadu, JE Morley - International journal of cardiology, 2015 - Elsevier
It has been estimated that 5.1 million Americans suffer from heart failure. Cognitive
impairment has been described as a consequence of heart failure in numerous studies …
impairment has been described as a consequence of heart failure in numerous studies …
Interleukin‐17 and ischaemic stroke
Q Zhang, Y Liao, Z Liu, Y Dai, Y Li, Y Li, Y Tang - Immunology, 2021 - Wiley Online Library
Summary Interleukin‐17 (IL‐17) is a cytokine family that includes 6 members, IL‐17A
through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to …
through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to …
HIF hydroxylase pathways in cardiovascular physiology and medicine
T Bishop, PJ Ratcliffe - Circulation research, 2015 - Am Heart Assoc
Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …
multiple cellular and systemic responses in response to changes in oxygen availability. The …
Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system
During the past 5 decades, it has been widely promulgated that the chemicals in plants that
are good for health act as direct scavengers of free radicals. Here we review evidence that …
are good for health act as direct scavengers of free radicals. Here we review evidence that …