Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …

Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus,
represent important therapeutic targets. These diverse functions highlight the heterogenous …

Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious
functions. However, the potential function of virus-trained macrophages in antitumor …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …