Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …

Background Enzymatic activity measurements of the highly oxidative enzyme
myeloperoxidase (MPO), which is implicated in many diseases, are widely used in the …

Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry
cell weight of neutrophils where it is predominantly found in the primary (azurophilic) …

Normal HDL activity confers cardiovascular and overall protection by mediating reverse
cholesterol transport and through its potent anti-inflammatory, antioxidant, and …

Carbamylation is a non-enzymatic post-translational modification in which cyanate binds to
molecules containing primary amine or thiol groups and forms carbamyl groups. Cyanate is …

Psoriasis, a chronic inflammatory skin disease, has been linked to increased myocardial
infarction and stroke. Functional impairment of HDL may contribute to the excess …

Alterations affecting high-density lipoproteins (HDLs) are one of the various abnormalities
observed in dyslipidemia in type 2 diabetes mellitus (T2DM) and obesity. Kinetic studies …

Post-translational modifications (PTMs) of proteins and peptides have recently gained much
attention, as they are involved in the pathogenesis of cardiovascular disease and eventually …

Protein carbamoylation is a non-enzymatic post-translational modification that binds
isocyanic acid, which can be derived from the dissociation of urea or from the …