Antiviral and antimicrobial nucleoside derivatives: structural features and mechanisms of action
The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
L Eyer, R Nencka, E de Clercq… - Antiviral Chemistry …, 2018 - journals.sagepub.com
Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …
In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications
A Pałasz, D Cież - European journal of medicinal chemistry, 2015 - Elsevier
This review article is an effort to summarize recent developments in researches providing
uracil derivatives with promising biological potential. This article also aims to discuss …
uracil derivatives with promising biological potential. This article also aims to discuss …
Dengue drug discovery: Progress, challenges and outlook
SP Lim - Antiviral research, 2019 - Elsevier
In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …
countries, but poses higher risks to unexposed individuals, the development of antivirals for …
Recent update on anti-dengue drug discovery
Dengue is the most important arthropod-borne viral disease of humans, with more than half
of the global population living in at-risk areas. Despite the negative impact on public health …
of the global population living in at-risk areas. Despite the negative impact on public health …
Structure and function of Zika virus NS5 protein: perspectives for drug design
Zika virus (ZIKV) belongs to the positive-sense single-stranded RNA-containing Flaviviridae
family. Its recent outbreak and association with human diseases (eg neurological disorders) …
family. Its recent outbreak and association with human diseases (eg neurological disorders) …
Nucleoside inhibitors of tick-borne encephalitis virus
Tick-borne encephalitis virus (TBEV) is a leading cause of human neuroinfections in Europe
and Northeast Asia. There are no antiviral therapies for treating TBEV infection. A series of …
and Northeast Asia. There are no antiviral therapies for treating TBEV infection. A series of …
Inhibitors compounds of the flavivirus replication process
Flaviviruses are small viruses with single-stranded RNA, which include the yellow fever
virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis …
virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis …
Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus
A Zacheo, J Hodek, D Witt, GF Mangiatordi, QK Ong… - Scientific reports, 2020 - nature.com
Dengue virus (DENV) causes 390 million infections per year. Infections can be
asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome …
asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome …
[HTML][HTML] Synthesis and evaluation of imidazole-4, 5-and pyrazine-2, 3-dicarboxamides targeting dengue and yellow fever virus
The results of a high-throughput screening assay using the dengue virus-2 replicon showed
that the imidazole 4, 5-dicarboxamide (I45DC) derivative (15a) has a high dengue virus …
that the imidazole 4, 5-dicarboxamide (I45DC) derivative (15a) has a high dengue virus …