Background Cancer is characterized by the rampant proliferation, growth, and infiltration of
malignantly transformed cancer cells past their normal boundaries into adjacent tissues. It is …

Purpose The impact of a personalized cancer treatment strategy (ie, matching patients with
drugs based on specific biomarkers) is still a matter of debate. Methods We reviewed phase …

Importance The impact of a biomarker-based (personalized) cancer treatment strategy in the
setting of phase 1 clinical trials was analyzed. Objective To compare patient outcomes in …

Introduction: Cancer is often diagnosed at late stages when the chance of cure is relatively
low and although research initiatives in oncology discover many potential cancer …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …

Background This systematic review aimed to gather evidence from research on the current
state of liquid biopsy in medical practice, specifically focusing on mutation detection and …

Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation
characterized by an increased risk of melanoma transformation during infancy or adulthood …

Phosphotransferases, also known as kinases, are the most intensively studied protein drug
target category in current pharmacological research, as evidenced by the vast number of …

Demand for new technologies that deliver fast, inexpensive and accurate genome
information has never been greater. This challenge has catalysed the rapid development of …

Germline testing for familial predisposition to myeloid malignancies is becoming more
common with the recognition of multiple familial syndromes. Currently, Clinical Laboratory …