Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Animal toxins acting on ion channels of excitable cells are principally highly potent short
peptides that are present in limited amounts in the venoms of various unrelated species …

The complexity of Australian funnel-web spider venoms has been explored via the
combined use of MALDI–TOF mass spectrometry coupled with chromatographic separation …

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we
provide an update on the topology of the cystine knot and the combinatorial diversity of …

This review on all spider venom components known by the end of 2010 bases on 1618
records for venom compounds from 174 spider species (= 0.41% of all known species) …

Insect peptides are key elements of the innate immunity against bacteria and fungi. These
molecules offer remarkable properties: high efficacy, a low probability of resistance, limited …

The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and
neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block …

The structure of a two-chain peptide formed by the treatment of the potent antimicrobial
peptide microcin J25 (MccJ25) with thermolysin has been characterized by NMR …

Cystine knot miniproteins define a class of peptides in the size range of approximately 28-35
amino acid residues that often combine high chemical and biological stability with high …

Epilepsy is characterised by spontaneous recurrent seizures that are caused by an
imbalance between neuronal excitability and inhibition. Since ion channels play …