The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The transcription factor SOX2 is expressed most notably in the develo** CNS and
placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

This review summarises the key clinical features of septo-optic dysplasia (SOD), the
significant inroads that progress in genetics has made into our understanding of the …

Obesity is an escalating epidemic, but an effective noninvasive therapy is still scarce. For
obesity treatment, anorexigenic neuropeptides are promising tools, but their delivery from …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Context: Heterozygous, de novo mutations in the transcription factor SOX2 are associated
with bilateral anophthalmia or severe microphthalmia and hypopituitarism. Variable …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

Septo-optic dysplasia (SOD) is a highly heterogeneous condition comprising variable
phenotypes including midline and forebrain abnormalities, optic nerve and pituitary …