Habituation is more than learning to ignore: multiple mechanisms serve to facilitate shifts in behavioral strategy

TA McDiarmid, AJ Yu, CH Rankin - BioEssays, 2019 - Wiley Online Library
Recent work indicates that there are distinct response habituation mechanisms that can be
recruited by different stimulation rates and that can underlie different components (eg, the …

Leveraging big data to uncover the eco-evolutionary factors sha** behavioural development

SM Ehlman, U Scherer, D Bierbach… - … of the Royal …, 2023 - royalsocietypublishing.org
Map** the eco-evolutionary factors sha** the development of animals' behavioural
phenotypes remains a great challenge. Recent advances in 'big behavioural data'research …

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation

TA McDiarmid, M Belmadani, J Liang… - Proceedings of the …, 2020 - National Acad Sciences
A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and
growing number of candidate risk genes and gene variants of unknown functional …

CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and …

TA McDiarmid, V Au, AD Loewen… - Disease Models & …, 2018 - journals.biologists.com
Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic
variation we discover. This presents a major challenge in the clinical setting, where the …

Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans

EL Ardiel, TA McDiarmid… - … of the Royal …, 2018 - royalsocietypublishing.org
Habituation is a ubiquitous form of non-associative learning observed as a decrement in
responding to repeated stimulation that cannot be explained by sensory adaptation or motor …

Networks of causal linkage between eigenmodes characterize behavioral dynamics of caenorhabditis elegans

E Saberski, AK Bock, R Goodridge… - PLoS computational …, 2021 - journals.plos.org
Behavioral phenoty** of model organisms has played an important role in unravelling the
complexities of animal behavior. Techniques for classifying behavior often rely on easily …

Behavioral genetics and genomics: Mendel's peas, mice, and bees

HE Hoekstra, GE Robinson - Proceedings of the National …, 2022 - National Acad Sciences
The question of the heritability of behavior has been of long fascination to scientists and the
broader public. It is now widely accepted that most behavioral variation has a genetic …

Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders

LD Kepler, TA McDiarmid, CH Rankin - Neurobiology of Learning and …, 2020 - Elsevier
Alterations in habituation, a highly conserved form of non-associative learning, are
suspected to contribute to a range of the complex behavioural phenotypes present in …

Supported high-throughput 3D culturing, trap**, and monitoring of Caenorhabditis elegans

M Tahernia, M Mohammadifar, S Choi - Micromachines, 2020 - mdpi.com
We developed an innovative paper-based platform for high-throughput culturing, trap**,
and monitoring of C. elegans. A 96-well array was readily fabricated by placing a nutrient …

Targeted thermal stimulation and high-content phenoty** reveal that the C. elegans escape response integrates current behavioral state and past experience

J Byrne Rodgers, WS Ryu - PLoS One, 2020 - journals.plos.org
The ability to avoid harmful or potentially harmful stimuli can help an organism escape
predators and injury, and certain avoidance mechanisms are conserved across the animal …