Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Reprogramming somatic fibroblasts into alternative lineages would provide a promising
source of cells for regenerative therapy. However, transdifferentiating human cells into …

Heart failure plagues industrialized nations, killing more people than any other disease. It
usually results from a deficiency of specialized cardiac muscle cells known as …

As the adult mammalian heart has limited potential for regeneration and repair, the loss of
cardiomyocytes during injury and disease can result in heart failure and death. The cellular …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Rationale: Repopulation of the injured heart with new, functional cardiomyocytes remains a
daunting challenge for cardiac regenerative medicine. An ideal therapeutic approach would …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Heart failure due to cardiomyocyte loss after ischemic heart disease is the leading cause of
death in the United States in large part because heart muscle regenerates poorly. The …