Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …

The lack of reliable predictive biomarkers to guide effective therapy is a major obstacle to the
advancement of therapy for high-grade gliomas, particularly glioblastoma (GBM), one of the …

Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …

Cyclin-dependent kinases (CDKs) play a key regulating role in the cell cycle, which is almost
universally altered in cancer, leading to sustained proliferation. Early pan-CDK inhibitors …

The discovery of cyclin-dependent kinases (CDK) and their mechanism in regulating the cell
cycle process was considered a game-changer in cancer therapy. Cell cycle arrest and …

Glioblastoma (GBM) is the most common and malignant tumour of the central nervous
system. Recent appreciation of the heterogeneity amongst these tumours not only changed …

PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both
histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays …

Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …