Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory

MZ Othman, Z Hassan, ATC Has - Experimental animals, 2022 - jstage.jst.go.jp
Since its development about 40 years ago (1981–2021), Morris water maze has turned into
a very popular tool for assessing spatial learning and memory. Its many advantages have …

Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders

E Doney, A Cadoret, L Dion‐Albert… - European Journal of …, 2022 - Wiley Online Library
Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress

O Yakovleva, K Bogatova, R Mukhtarova, A Yakovlev… - Biomolecules, 2020 - mdpi.com
Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids,
including homocysteine and exerts neuroprotective effects. An increase of homocysteine …

Search strategy analysis of Tg4-42 Alzheimer Mice in the Morris Water Maze reveals early spatial navigation deficits

N Curdt, FW Schmitt, C Bouter, T Iseni, HC Weile… - Scientific Reports, 2022 - nature.com
Spatial disorientation is one of the earliest symptoms in Alzheimer's disease and allocentric
deficits can already be detected in the asymptomatic preclinical stages of the disease. The …

Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges

J Rodrigues, E Studer, S Streuber, N Meyer… - Nature …, 2020 - nature.com
Individuals differ in their physiological responsiveness to stressful challenges, and stress
potentiates the development of many diseases. Heart rate variability (HRV), a measure of …

Effects of vitamin D in an animal model of Alzheimer's disease: Behavioral assessment with biochemical investigation of Hippocampus and serum

N Mehri, R Haddadi, M Ganji, S Shahidi… - Metabolic brain …, 2020 - Springer
Regulatory role of vitamin D (VitD) in cognitive memory and learning has been proposed.
Here, we examine the behavioral and biochemical effects of VitD in Alzheimer's disease …

Behavioral characteristics as potential biomarkers of the development and phenotype of epilepsy in a rat model of temporal lobe epilepsy

K Nizinska, K Szydlowska, A Vouros, A Kiryk… - Scientific Reports, 2021 - nature.com
The present study performed a detailed analysis of behavior in a rat model of epilepsy using
both established and novel methodologies to identify behavioral impairments that may …

Pathfinder: open source software for analyzing spatial navigation search strategies

MB Cooke, TP O'Leary, P Harris, R Ma… - …, 2020 - pmc.ncbi.nlm.nih.gov
Spatial navigation is a universal behavior that varies depending on goals, experience and
available sensory stimuli. Spatial navigational tasks are routinely used to study learning …

Effects of mongolian warm acupuncture on iNOS/NO and inflammatory cytokines in the hippocampus of chronic fatigue rats

L Shui, RN Yi, YJ Wu, SM Bai, Q Si, A Bo… - Frontiers in Integrative …, 2020 - frontiersin.org
The inducible nitric oxide synthase/nitric oxide (iNOS/NO) signaling pathway and
inflammatory cytokines play important roles in the pathogenesis of exercise-induced fatigue …

A semi-supervised sparse K-Means algorithm

A Vouros, E Vasilaki - Pattern Recognition Letters, 2021 - Elsevier
We consider the problem of data clustering with unidentified feature quality and when a
small amount of labelled data is provided. An unsupervised sparse clustering method can …