Similarities in neocortical circuit organization across areas and species suggest a common
strategy to process diverse types of information, including sensation from diverse modalities …

Neuronal oscillations are ubiquitous in the brain and may contribute to cognition in several
ways: for example, by segregating information and organizing spike timing. Recent data …

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …

Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …

γ-Aminobutyric acid (GABA) ergic inputs are strategically positioned to gate synaptic
integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal …

Optogenetics allows manipulations of genetically and spatially defined neuronal populations
with excellent temporal control. However, neurons are coupled with other neurons over …