Cuproptosis was a copper-dependent and unique kind of cell death that was separate from
existing other forms of cell death. The last decade has witnessed a considerable increase in …

Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that
activates the immune system to induce cancer attacks. Among them, immune checkpoint …

Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past,
elesclomol was recognized as an inducer of oxidative stress, but now it has also been found …

The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids,
flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants …

Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …