Asymmetric multicomponent reactions involve the preparation of chiral compounds by the
reaction of three or more reagents added simultaneously. This kind of addition and reaction …

Transition-metal-catalyzed nucleophilic addition of organometallic reagents to polar
unsaturated substrates is one of the most important and powerful bond-forming strategies …

The addition of an organometallic reagent to a carbonyl compound or an imine represents
an important process in synthetic organic chemistry because in this reaction, together with a …

Chiral tertiary alcohols and R-tertiary amines are important building blocks of naturally
occurring and artificial biologically active molecules. Although there are catalytic asymmetric …

Asymmetric metal based catalysis has advanced quickly in recent years, with its efficiency
relying exclusively on chiral ligands. Rational design and meticulous selection of chiral …

Chiral tertiary alcohols are an important class of organic compounds which have found wide
applications in both academia and industry. Therefore, various synthetic strategies towards …

There is a growing need in organic synthesis for efficient methodologies for the asymmetric
synthesis of quaternary carbon centres. One of the most attractive and straightforward …

In an age when organic chemists have shown that even the most complex natural and
unnatural products can be synthesized, 1-3 the emphasis of synthetic chemistry is shifting to …

The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the
beginning of this century became a true milestone in the growth of organocatalysis as a …

Enantioselective allylation is a highly used organic reaction to prepare chiral homoallylic
alcohols and amines, which serve as important building blocks in the synthesis of a variety …