Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …

The autosomal dominant cerebellar ataxias (ADCAs) represent a heterogeneous group of
neurodegenerative diseases with progressive ataxia and cerebellar degeneration. The …

A CAG repeat sequence in the ATXN2 gene encodes a polyglutamine (polyQ) tract within
the ataxin-2 (ATXN2) protein, showcasing a complex landscape of functions that have been …

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …

The autosomal dominant cerebellar ataxias, referred to as spinocerebellar ataxias in genetic
nomenclature, are a rare group of progressive neurodegenerative disorders characterized …

The discovery in the 1980s that protein kinase C (PKC) is a receptor for the tumor-promoting
phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials …

Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …

The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar
atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally …

Background In broilers, high ambient temperature can result in reduced feed consumption,
digestive inefficiency, impaired metabolism, and even death. The broiler sector of the US …