Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis
are among the most common reasons for mortality in humans at present. Nanostructured …

Natural bone is a mineralized biological material, which serves a supportive and protective
framework for the body, stores minerals for metabolism, and produces blood cells nourishing …

Promoting bone regeneration and repairing defects are urgent and critical challenges in
orthopedic clinical practice. Research on bone substitute biomaterials is essential for …

Physical cues like morphology, light, electric signal, mechanic signal, magnetic signal, and
heat can be used as alternative regulators for expensive but short‐acting growth factors in …

The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major
problem in our super-aging society. Bone regeneration is one of the main topics of concern …

Mesenchymal stem cells (MSCs) have been identified in many adult tissues. MSCs can
regenerate through cell division or differentiate into adipocytes, osteoblasts and …

Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of
gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with …

Over the past decades, age-related pathologies have increased abreast the aging
population worldwide. The increased age of the population indicates that new tools, such as …

Despite the recent advances in the development of bone graft substitutes, treatment of
critical size bone defects continues to be a significant challenge, especially in the elderly …

Lesions with bone loss may require autologous grafts, which are considered the gold
standard; however, natural or synthetic biomaterials are alternatives that can be used in …