The role of phosphatidylserine recognition receptors in multiple biological functions

MB Naeini, V Bianconi, M Pirro, A Sahebkar - Cellular & molecular biology …, 2020 - Springer
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Phosphatidylserine: A cancer cell targeting biomarker

B Sharma, SS Kanwar - Seminars in cancer biology, 2018 - Elsevier
Cancer is a leading cause of mortality and morbidity globally. Many prominent cancer-
associated molecules have been identified over the recent years which include EGFR …

Targeting phosphatidylserine for Cancer therapy: prospects and challenges

W Chang, H Fa, D **ao, J Wang - Theranostics, 2020 - pmc.ncbi.nlm.nih.gov
Cancer is a leading cause of mortality and morbidity worldwide. Despite major
improvements in current therapeutic methods, ideal therapeutic strategies for improved …

Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium

SD Vallabhapurapu, VM Blanco, MK Sulaiman… - …, 2015 - pmc.ncbi.nlm.nih.gov
Viable cancer cells expose elevated levels of phosphatidylserine (PS) on the exoplasmic
face of the plasma membrane. However, the mechanisms leading to elevated PS exposure …

[HTML][HTML] Phosphatidylserine: The unique dual-role biomarker for cancer imaging and therapy

A Kaynak, HW Davis, AB Kogan, JH Lee… - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy, radiotherapy and surgery are the primary therapies for
cancer. Even with these current treatment modalities, the death rate for many cancers is still …

SapC-DOPS–a Phosphatidylserine-targeted Nanovesicle for selective Cancer therapy

KF N'Guessan, PH Patel, X Qi - Cell Communication and Signaling, 2020 - Springer
Phosphatidylserine (PS) is normally located in the inner leaflet of the membrane bilayer of
healthy cells, however it is expressed at high levels on the surface of cancer cells. This has …

Krill oil: nutraceutical potential in skin health and disease

L Duo, J Yang, X Wang, G Zhang, J Zhao, H Zou… - Frontiers in …, 2024 - frontiersin.org
Krill oil (KO), extracted from the Antarctic marine crustacean Euphausia superba, is a
nutrient-dense substance that includes rich profiles of n-3 polyunsaturated fatty acids (n-3 …

Phosphatidylserine-selective targeting and anticancer effects of SapC-DOPS nanovesicles on brain tumors

VM Blanco, Z Chu, SD Vallabhapurapu… - …, 2014 - pmc.ncbi.nlm.nih.gov
Brain tumors, either primary (eg, glioblastoma multiforme) or secondary (metastatic), remain
among the most intractable and fatal of all cancers. We have shown that nanovesicles …

Enhanced phosphatidylserine-selective cancer therapy with irradiation and SapC-DOPS nanovesicles

HW Davis, SD Vallabhapurapu, Z Chu… - …, 2019 - pmc.ncbi.nlm.nih.gov
Normal living cells exhibit phosphatidylserine (PS) primarily within the intracellular leaflet of
the plasma membrane. In contrast, viable cancer cells have high levels of PS on the external …

Targeting and cytotoxicity of SapC-DOPS nanovesicles in pancreatic cancer

Z Chu, S Abu-Baker, MB Palascak, SA Ahmad… - PloS one, 2013 - journals.plos.org
Only a small number of promising drugs target pancreatic cancer, which is the fourth leading
cause of cancer deaths with a 5-year survival of less than 5%. Our goal is to develop a new …