LINE-1 elements in structural variation and disease
CR Beck, JL Garcia-Perez, RM Badge… - Annual review of …, 2011 - annualreviews.org
The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …
study and discovery of human transposable elements. It now is undeniable that …
The influence of LINE‐1 and SINE retrotransposons on mammalian genomes
Transposable elements (TEs) or “jum** genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health
Transposable elements (TEs) have shared an exceptionally long coexistence with their host
organisms and have come to occupy a significant fraction of eukaryotic genomes. The bulk …
organisms and have come to occupy a significant fraction of eukaryotic genomes. The bulk …
LINE-1 protein localization and functional dynamics during the cell cycle
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex
JL Goodier, L Zhang, MR Vetter… - Molecular and cellular …, 2007 - Taylor & Francis
LINE-1 retrotransposons constitute one-fifth of human DNA and have helped shape our
genome. A full-length L1 encodes a 40-kDa RNA-binding protein (ORF1p) and a 150-kDa …
genome. A full-length L1 encodes a 40-kDa RNA-binding protein (ORF1p) and a 150-kDa …
Characterization of LINE-1 ribonucleoprotein particles
AJ Doucet, AE Hulme, E Sahinovic, DA Kulpa… - PLoS …, 2010 - journals.plos.org
The average human genome contains a small cohort of active L1 retrotransposons that
encode two proteins (ORF1p and ORF2p) required for their mobility (ie, retrotransposition) …
encode two proteins (ORF1p and ORF2p) required for their mobility (ie, retrotransposition) …
Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition
Abstract The LINE-1 (L1) retrotransposon emerges as a major source of human
interindividual genetic variation, with important implications for evolution and disease. L1 …
interindividual genetic variation, with important implications for evolution and disease. L1 …
Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame
Non-LTR retrotransposons (NLRs) are a unique class of mobile genetic elements that have
significant impact on the evolution of eukaryotic genomes. However, the molecular details …
significant impact on the evolution of eukaryotic genomes. However, the molecular details …
Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain
Long interspersed nuclear element-1 (L1) is a retrotransposable element that autonomously
replicates in the human genome, resulting in DNA damage and genomic instability …
replicates in the human genome, resulting in DNA damage and genomic instability …
Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5′ untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap …
Retrotransposon L1 is a mobile genetic element of the LINE family that is extremely
widespread in the mammalian genome. It encodes a dicistronic mRNA, which is …
widespread in the mammalian genome. It encodes a dicistronic mRNA, which is …