The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Polycystic ovary syndrome (PCOS) is a common endocrinopathy occurring in reproductive-
age women. Hyperandrogenism, polycystic ovaries, chronic anovulation, and metabolic …

Infertility affects one in six of the population and increasingly couples require treatment with
assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Context Polycystic ovary syndrome (PCOS) is the most common cause of anovulation. A key
feature of PCOS is arrest of follicles at the small-to medium-sized antral stage. Objective and …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and is the leading cause of anovulatory subfertility. Increased …

Polycystic ovary syndrome is characterised by excessive levels of androgens and ovulatory
dysfunction, and is a common endocrine disorder in women of reproductive age. Polycystic …

STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and
ovulation in preclinical models and anovulatory women with polycystic ovary syndrome …

In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …