Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

C Schiano, G Benincasa, M Franzese… - Pharmacology & …, 2020 - Elsevier
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis

C Eyileten, Z Wicik, S De Rosa, D Mirowska-Guzel… - Cells, 2018 - mdpi.com
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

A Rahmani, K Saleki, N Javanmehr… - Ageing research …, 2020 - Elsevier
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …

[HTML][HTML] Rho/ROCK pathway and noncoding RNAs: implications in ischemic stroke and spinal cord injury

T Kimura, Y Horikoshi, C Kuriyagawa… - International journal of …, 2021 - mdpi.com
Ischemic strokes (IS) and spinal cord injuries (SCI) are major causes of disability. RhoA is a
small GTPase protein that activates a downstream effector, ROCK. The up-regulation of the …

Increased serum exosomal miR-134 expression in the acute ischemic stroke patients

J Zhou, L Chen, B Chen, S Huang, C Zeng, H Wu… - BMC neurology, 2018 - Springer
Background The exosomal miRNAs have been emerged as biomarkers and therapeutic
targets for various diseases, however, the function of exosomal miRNAs in stroke remains …

Gold nanoparticle couples with entropy-driven toehold-mediated DNA strand displacement reaction on magnetic beads: toward ultrasensitive energy-transfer-based …

N Zhang, XM Shi, HQ Guo, XZ Zhao, WW Zhao… - Analytical …, 2018 - ACS Publications
Highly stable circulating microRNAs (miRNAs) are currently recognized as a novel potential
biomarker for clinical cancer diagnosis in the early stage. However, limited by its low …

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in …

R Tian, B Wu, C Fu, K Guo - Aging (Albany NY), 2020 - pmc.ncbi.nlm.nih.gov
Stroke is a leading cause of death and disability worldwide. The purpose of this study was to
investigate the possible role of the microRNA (miRNA or miR) miR-137 in ischemic stroke …

Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke

SS Sørensen, AB Nygaard, AL Carlsen… - Biomarker …, 2017 - Springer
Background The purpose of this study was to investigate the potential of cerebrospinal fluid
miRNAs as diagnostic biomarkers of acute ischemic stroke using three different profiling …

Differential long noncoding RNA expressions in peripheral blood mononuclear cells for detection of acute ischemic stroke

QW Deng, S Li, H Wang, HL Sun, L Zuo, ZT Gu… - Clinical …, 2018 - portlandpress.com
Long noncoding RNAs (lncRNAs) have been highlighted to be involved in the pathological
process of ischemic stroke (IS). The purpose of the present study was to investigate the …

[HTML][HTML] Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13

D Jiang, X Sun, S Wang, H Man - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Ischemic stroke represents a major cause of adult physical disability, which is triggered by
cerebral artery occlusion induced blood flow blockage. MiR-874-3p has been reported to be …