Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

[HTML][HTML] A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

Z Li, T Zhao, J Ding, H Gu, Q Wang, Y Wang, D Zhang… - Bioactive materials, 2023 - Elsevier
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by
complicated inflammation-related pathological processes, such as excessive reactive …

Carrier-free nanodrug based on co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C **ao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

[HTML][HTML] Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z **ao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Management of acute traumatic spinal cord injury: a review of the literature

TY Wang, C Park, H Zhang, S Rahimpour… - Frontiers in …, 2021 - frontiersin.org
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional
and economic burden on both the individual and societal levels. Prognosis is dependent on …

Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual‐signal transform‐based selenium antioxidant

Z Ji, J Zheng, Y Ma, H Lei, W Lin, J Huang, H Yang… - Small, 2023 - Wiley Online Library
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and
irreversible pathological deterioration of the central nervous system. Thus, preventing …

[HTML][HTML] ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair

R Hua, C Zhao, Z Xu, D Liu, W Shen, W Yuan, Y Li… - Bioactive Materials, 2024 - Elsevier
Spinal cord injury (SCI) is a traumatic condition that results in impaired motor and sensory
function. Ferroptosis is one of the main causes of neural cell death and loss of neurological …

An update of a clinical practice guideline for the management of patients with acute spinal cord injury: recommendations on the role and timing of decompressive …

MG Fehlings, LA Tetreault, L Hachem… - Global Spine …, 2024 - journals.sagepub.com
Study Design Clinical practice guideline development. Objectives Acute spinal cord injury
(SCI) can result in devastating motor, sensory, and autonomic impairment; loss of …