[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

[HTML][HTML] Quorum Sensing Inhibitors to Quench P. aeruginosa Pathogenicity

M Duplantier, E Lohou, P Sonnet - Pharmaceuticals, 2021 - mdpi.com
The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …

3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa

ZY Miao, XY Zhang, MH Yang, YJ Huang… - Journal of Medicinal …, 2023 - ACS Publications
The development of quorum sensing inhibitors capable of decreasing the production of
virulence factors is an effective strategy to overcome resistance in Pseudomonas …

[HTML][HTML] Strategies for quorum sensing inhibition as a tool for controlling Pseudomonas aeruginosa infections

B Rodríguez-Urretavizcaya, L Vilaplana… - International journal of …, 2024 - Elsevier
Antibiotic resistance is one of the most important concerns in global health today. A growing
number of infections are becoming harder to treat with conventional drugs and fewer new …

Communication Breakdown: Into the Molecular Mechanism of Biofilm Inhibition by CeO2 Nanocrystal Enzyme Mimics and How It Can Be Exploited

E Pütz, A Gazanis, NG Keltsch, O Jegel, F Pfitzner… - ACS …, 2022 - ACS Publications
Bacterial biofilm formation is a huge problem in industry and medicine. Therefore, the
discovery of anti-biofilm agents may hold great promise. Biofilm formation is usually a …

Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections

TM Hibbert, M Whiteley, SA Renshaw… - Critical reviews in …, 2024 - Taylor & Francis
Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in
people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF …

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance

RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …

Design of Quorum Sensing Inhibitor–Polymer Conjugates to Penetrate Pseudomonas aeruginosa Biofilms

F Soukarieh, P Gurnani, M Romero, N Halliday… - ACS Macro …, 2023 - ACS Publications
Antimicrobial resistance (AMR) is a global threat to public health with a forecast of a
negative financial impact of one trillion dollars per annum, hence novel therapeutics are …

Multidrug-Resistant Bacteria Quorum-Sensing Inhibitors: a particular focus on Pseudomonas aeruginosa.

A Maiga, M Ampomah-Wireko, LH Teng, FZ Min… - European Journal of …, 2024 - Elsevier
Many widely used conventional antibiotics have failed to show clinical efficacy against
Pseudomonas aeruginosa (P. aeruginosa) due to the strain's rising resistance to most …

Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa

S Sabir, T Das, R Kuppusamy, TT Yu, MDP Willcox… - Bioorganic …, 2023 - Elsevier
It is well established that the quorum sensing (QS) in Pseudomonas aeruginosa is primarily
responsible for the synthesis and the release of several virulence factors including …