Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in
the context of various neurological diseases. The high prevalence of fatigue as either a …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Among patients with multiple sclerosis (MS), fatigue is the most commonly reported
symptom, and one of the most debilitating. Despite its high prevalence and significant …

Data suggest that cytokines released during the inflammatory response target subcortical
structures including the basal ganglia as well as dopamine function to acutely induce …

Background Methylphenidate, modafinil, and amantadine are commonly prescribed
medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting …

Fatigue is one of the most pervasive symptoms of multiple sclerosis (MS), and has
engendered hundreds of investigations on the topic. While there is a growing literature using …

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

Fatigue is a common symptom of multiple sclerosis (MS) with negative impacts extending
from general functioning to quality of life. Both the cause and consequences of MS fatigue …