Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

The role of microglia in retinal neurodegeneration: Alzheimer's disease, Parkinson, and glaucoma

AI Ramirez, R de Hoz, E Salobrar-Garcia… - Frontiers in aging …, 2017 - frontiersin.org
Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

JA Fernández-Albarral, R De Hoz… - Neural regeneration …, 2020 - journals.lww.com
Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a
medicinal plant. It currently has numerous therapeutic properties attributed to it, such as …

Astragaloside IV supplementation promotes a neuroprotective effect in experimental models of neurological disorders: a systematic review

IM Costa, FOV Lima, LCB Fernandes… - Current …, 2019 - ingentaconnect.com
Background: Neurological disorders constitute a growing worldwide concern due to the
progressive aging of the population and the risky behavior they represent. Herbal medicines …

Pain modulation by nitric oxide in the spinal cord.

MAM Freire, JS Guimarães, W Gomes-Leal… - Frontiers in …, 2009 - frontiersin.org
Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing
effects. In the central nervous system (CNS), NO synthesis is primarily triggered by activation …

Comprehensive analysis of tissue preservation and recording quality from chronic multielectrode implants

MAM Freire, E Morya, J Faber, JR Santos… - PloS one, 2011 - journals.plos.org
Multielectrodes have been used with great success to simultaneously record the activity of
neuronal populations in awake, behaving animals. In particular, there is great promise in the …

What happens in TBI? A wide talk on animal models and future perspective

S Kundu, S Singh - Current neuropharmacology, 2023 - benthamdirect.com
Traumatic brain injury (TBI) is a global healthcare concern and a leading cause of death.
The most common causes of TBI include road accidents, sports injuries, violence in …

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

MT Viscomi, M D'Amelio, V Cavallucci, L Latini… - Autophagy, 2012 - Taylor & Francis
Autophagy is the evolutionarily conserved degradation and recycling of cellular constituents.
In mammals, autophagy is implicated in the pathogenesis of many neurodegenerative …

[PDF][PDF] Pathophysiology of neurodegeneration following traumatic brain injury.

MAM Freire - West Indian Medical Journal, 2012 - researchgate.net
Acute neuropathological conditions, including brain and spinal cord trauma, are leading
causes of death and disabilities worldwide, especially in children and young adults. The …

The complexity of secondary cascade consequent to traumatic brain injury: pathobiology and potential treatments

N Khatri, B Sumadhura, S Kumar… - Current …, 2021 - benthamdirect.com
According to the World Health Organization, Traumatic brain injury (TBI) is the major cause
of death and disability and will surpass the other diseases by the year 2020. Patients who …