Schizophrenia risk has often been conceptualized using a model which requires two hits in
order to generate the clinical phenotype—the first as an early priming in a genetically …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …

Schizophrenia is a severe and debilitating mental disorder which, despite the move towards
community care, still accounts for more hospital bed occupancy than any other disease …

Highlights•ACh boosts attention by enhancing sensory stimuli and decreasing cortico-
cortical communication.•Increased ACh signaling can lead to symptoms of depression in …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal
cognitive performance. Despite the fact that many have studied how ACh affects neuronal …

Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …

Schizophrenia is a devastating mental illness and its effective treatment is among the most
challenging issues in psychiatry. The symptoms of schizophrenia are heterogeneous …

Aripiprazole was the first antipsychotic developed to possess agonist properties at
dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for …