BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

Cells organize many of their biochemical reactions in non-membrane compartments. Recent
evidence has shown that many of these compartments are liquids that form by phase …

Intracellular organelles are either membrane-bound vesicles or membrane-less
compartments that are made up of proteins and RNA. These organelles play key biological …

Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-
separated mechanical bodies during mitosis,,. This enables chromosomes to move …

Exciting recent developments suggest that phase transitions represent an important and
ubiquitous mechanism underlying intracellular organization. We describe key experimental …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Biological cells are highly organized, with numerous subcellular compartments.
Phosphorylation has been hypothesized as a means to control the assembly/disassembly of …