Obesity is a modifiable cardiovascular risk factor, but adipose tissue (AT) depots in humans
are anatomically, histologically, and functionally heterogeneous. For example, visceral AT is …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Background Coronary computed tomography angiography (CCTA) is the first line
investigation for chest pain, and it is used to guide revascularisation. However, the …

The global prevalence of obesity has more than doubled over the past four decades,
currently affecting more than a billion individuals. Beyond its recognition as a high-risk …

Cardiac computed tomography (CT) was initially developed as a non-invasive diagnostic
tool to detect and quantify coronary stenosis. Thanks to the rapid technological …

Objectives The purpose of this study was to systematically explore the added value of
biomarkers of vascular inflammation for cardiovascular prognostication on top of clinical risk …

Background Epicardial adipose tissue (EAT) volume is a marker of visceral obesity that can
be measured in coronary computed tomography angiograms (CCTA). The clinical value of …

Vascular inflammation is a key driver in atherosclerotic progression and plaque rupture.
Recent evidence has shown that coronary computed tomography provides a noninvasive …

Coronary computed tomography angiography (CCTA) is increasingly the cornerstone in the
management of patients with chronic coronary syndromes. This fact is reflected by current …

Coronary artery disease (CAD) remains the leading cause of adult mortality globally.
Targeting known modifiable risk factors has had substantial benefit, but there remains a …