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Spin hyperpolarization in modern magnetic resonance
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …
disciplines and in various practical applications, with medical magnetic resonance imaging …
Parahydrogen‐based hyperpolarization for biomedicine
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …
14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing
The selective modification of nitrogen heteroaromatics enables the development of new
chemical tools and accelerates drug discovery. While methods that focus on expanding or …
chemical tools and accelerates drug discovery. While methods that focus on expanding or …
Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …
various techniques for the hyperpolarization of different molecules. Such approaches can …
15NRORC: An Azine Labeling Protocol
A practical method for the synthesis of 15N-labeled azines with a high degree of isotopic
enrichment is described. Activation of azine heterocycles with an electron-deficient arene …
enrichment is described. Activation of azine heterocycles with an electron-deficient arene …
Synthesis of 15N-Pyridines and Higher Mass Isotopologs via Zincke Imine Intermediates
HMH Nguyen, DC Thomas, MA Hart… - Journal of the …, 2024 - ACS Publications
Methods to incorporate stable radioisotopes are integral to pharmaceutical and
agrochemical development. However, despite the prevalence of pyridines in candidate …
agrochemical development. However, despite the prevalence of pyridines in candidate …
Signal amplification by reversible exchange (SABRE): From discovery to diagnosis
Signal amplification by reversible exchange (SABRE) turns typically weak magnetic
resonance responses into strong signals making previously impractical measurements …
resonance responses into strong signals making previously impractical measurements …
Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange
Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that
ordinarily impractical measurements become possible. The potential to revolutionize …
ordinarily impractical measurements become possible. The potential to revolutionize …
Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
Generalizing, extending, and maximizing nitrogen-15 hyperpolarization induced by parahydrogen in reversible exchange
Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR
hyperpolarization method that uses cheap and readily available para-hydrogen as a …
hyperpolarization method that uses cheap and readily available para-hydrogen as a …