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[HTML][HTML] Human placental development and function
The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …
Development of the human placenta
The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …
placental formation underpins common pregnancy disorders such as pre-eclampsia and …
Single-cell reconstruction of the early maternal–fetal interface in humans
During early human pregnancy the uterine mucosa transforms into the decidua, into which
the fetal placenta implants and where placental trophoblast cells intermingle and …
the fetal placenta implants and where placental trophoblast cells intermingle and …
Pre-eclampsia: pathophysiology and clinical implications
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …
presentation is highly variable but hypertension and proteinuria are usually seen. These …
[HTML][HTML] Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia
Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …
successful placentation and normal placental function. It is an intricate process that involves …
Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways
CWG Redman, AC Staff, JM Roberts - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother
to cause a range of responses that comprise the second stage (preeclampsia syndrome) …
to cause a range of responses that comprise the second stage (preeclampsia syndrome) …
Tracking placental development in health and disease
Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …
Pathophysiology of placental-derived fetal growth restriction
Placental-related fetal growth restriction arises primarily due to deficient remodeling of the
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …
Immune responses at the maternal-fetal interface
Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus
must be supported within the pregnant female for the required gestational period …
must be supported within the pregnant female for the required gestational period …