Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Promising antiviral activities of natural flavonoids against SARS-CoV-2 targets: systematic review

R Kaul, P Paul, S Kumar, D Büsselberg… - International journal of …, 2021 - mdpi.com
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …

The therapeutic potential of natural dietary flavonoids against SARS-CoV-2 infection

Z Wang, L Yang - Nutrients, 2023 - mdpi.com
The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin
3-gallate and myricetin, for health improvement and disease treatment has recently attracted …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Perspectives on SARS-CoV-2 main protease inhibitors

K Gao, R Wang, J Chen, JJ Tepe… - Journal of medicinal …, 2021 - ACS Publications
The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …

Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

Y Xu, AK Rashwan, AI Osman… - Environmental …, 2023 - Springer
Metal–organic frameworks are porous polymeric materials formed by linking metal ions with
organic bridging ligands. Metal–organic frameworks are used as sensors, catalysts for …

Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19

AK Ghosh, JL Mishevich, A Mesecar… - ChemMedChem, 2022 - Wiley Online Library
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …

[HTML][HTML] Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

C Ma, H Tan, J Choza, Y Wang, J Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract SARS-CoV-2 main protease (M pro) is one of the most extensively exploited drug
targets for COVID-19. Structurally disparate compounds have been reported as M pro …

A comprehensive review about the molecular structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Insights into natural products against …

EM Saied, YA El-Maradny, AA Osman, AMG Darwish… - Pharmaceutics, 2021 - mdpi.com
In 2019, the world suffered from the emergence of COVID-19 infection, one of the most
difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have …