Chemical reactors are employed to produce several materials, which are utilized in
numerous applications. The wide use of these chemical engineering units shows their …

Highlights•Presents PSE contributions to mAb process development.•Promotes integration
of process, host cell and developed products design.•Highlights mechanistic modeling blind …

CADET is an open source modeling and simulation framework for column liquid
chromatography. The software is freely distributed to both academia and industry under the …

The translation of cell therapies into clinical practice requires a scalable, efficient and cost-
effective manufacturing process. This paper presents an integrated experimental and cost …

Life‐cycle assessment (LCA) is an environmental assessment tool that quantifies the
environmental impact associated with a product or a process (eg, water consumption …

The potential of continuous bioprocessing is hindered by the bottlenecks of chromatography
processing, which continues to be executed in batch mode. Highlighting the critical …

This work addresses the integrated optimization of upstream and downstream processing
strategies of a monoclonal antibody (mAb) under uncertainty. In the upstream processing …

This paper presents a flexible genetic algorithm optimisation approach for multi-objective
biopharmaceutical planning problems under uncertainty. The optimisation approach …

This work addresses the multi-objective optimisation of manufacturing strategies of
monoclonal antibodies under uncertainty. The chromatography sequencing and column …

This work addresses the multiscale optimization of the purification processes of antibody
fragments. Chromatography decisions in the manufacturing processes are optimized …