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Synthetic lethality and cancer
A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …
alone is viable but the perturbation of both genes simultaneously results in the loss of …
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
The genetic concept of synthetic lethality has now been validated clinically through the
demonstrated efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of …
demonstrated efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of …
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
Although single-gene perturbation screens have revealed a number of new targets,
vulnerabilities specific to frequently altered drivers have not been uncovered. An important …
vulnerabilities specific to frequently altered drivers have not been uncovered. An important …
Gene essentiality and synthetic lethality in haploid human cells
Although the genes essential for life have been identified in less complex model organisms,
their elucidation in human cells has been hindered by technical barriers. We used extensive …
their elucidation in human cells has been hindered by technical barriers. We used extensive …
A highly characterized yeast toolkit for modular, multipart assembly
Saccharomyces cerevisiae is an increasingly attractive host for synthetic biology because of
its long history in industrial fermentations. However, until recently, most synthetic biology …
its long history in industrial fermentations. However, until recently, most synthetic biology …
CRISPRi and CRISPRa screens in mammalian cells for precision biology and medicine
Next-generation DNA sequencing technologies have led to a massive accumulation of
genomic and transcriptomic data from patients and healthy individuals. The major challenge …
genomic and transcriptomic data from patients and healthy individuals. The major challenge …
Map** the genetic landscape of human cells
Seminal yeast studies have established the value of comprehensively map** genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …
Systematic analysis of complex genetic interactions
INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …
result in a phenotype that is different from expectation based on those of the individual …
Identification and characterization of essential genes in the human genome
Large-scale genetic analysis of lethal phenotypes has elucidated the molecular
underpinnings of many biological processes. Using the bacterial clustered regularly …
underpinnings of many biological processes. Using the bacterial clustered regularly …
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
Combinatorial genetic screening using CRISPR–Cas9 is a useful approach to uncover
redundant genes and to explore complex gene networks. However, current methods suffer …
redundant genes and to explore complex gene networks. However, current methods suffer …