Poxviruses as a group can infect a large number of animals. However, at the level of
individual viruses, even closely related poxviruses display highly diverse host ranges and …

Despite the success of the WHO-led smallpox eradication programme a quarter of a century
ago, there remains considerable fear that variola virus, or other related pathogenic …

A previous comparative-genomic study of large nuclear and cytoplasmic DNA viruses
(NCLDVs) of eukaryotes revealed the monophyletic origin of four viral families: poxviruses …

The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

The duality of liquid-liquid phase separation (LLPS) of cellular components into
membraneless organelles defines the nucleation of both normal and disease processes …

Myxoma virus is a poxvirus naturally found in two American leporid (rabbit) species
(Sylvilagus brasiliensis and Sylvilagus bachmani) in which it causes an innocuous localised …

The versatility of ubiquitin in regulating protein function and cell behaviour through post-
translational protein modification makes it a particularly attractive target for viruses. Here we …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell
factors required during vaccinia virus infection. Validation and analysis of clustered hits …

Poxviruses are widespread pathogens, which display extremely different host ranges.
Whereas some poxviruses, including variola virus, display narrow host ranges, others such …