Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
tRNA dysregulation and disease
EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
Vaccination in patients with kidney failure: lessons from COVID-19
Infection is the second leading cause of death in patients with chronic kidney disease (CKD).
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein 9 nuclease (Cas9) system is being harnessed as a powerful tool for genome …
protein 9 nuclease (Cas9) system is being harnessed as a powerful tool for genome …
[HTML][HTML] The functions and unique features of LncRNAs in cancer development and tumorigenesis
Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …
Structure and function of long noncoding RNAs in epigenetic regulation
Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs
MJ Hangauer, IW Vaughn, MT McManus - PLoS genetics, 2013 - journals.plos.org
Known protein coding gene exons compose less than 3% of the human genome. The
remaining 97% is largely uncharted territory, with only a small fraction characterized. The …
remaining 97% is largely uncharted territory, with only a small fraction characterized. The …
Circular RNAs as emerging players in cervical cancer tumorigenesis; a review to roles and biomarker potentials
S Najafi - International Journal of Biological Macromolecules, 2022 - Elsevier
Cervical cancer is the most lethal gynecological cancer among women worldwide. Most of
the patients are diagnosed at the advanced stages due to late diagnosis and lack of …
the patients are diagnosed at the advanced stages due to late diagnosis and lack of …
The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …