[HTML][HTML] Cell-penetrating peptide-based delivery of macromolecular drugs: development, strategies, and progress

Z Sun, J Huang, Z Fishelson, C Wang, S Zhang - Biomedicines, 2023 - mdpi.com
Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Bioinspired Tumor‐Targeting and Biomarker‐Activatable Cell‐Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization

X Yang, S Gao, B Yang, Z Yang, F Lou… - Advanced …, 2023 - Wiley Online Library
Osteosarcoma is an aggressive malignant tumor that primarily develops in children and
adolescents. The conventional treatments for osteosarcoma often exert negative effects on …

Tumor microenvironment-responsive cell-penetrating peptides: design principle and precision delivery

C Wang, B Wang, Q Zhang, S Zhang - Colloids and Surfaces B …, 2024 - Elsevier
Cell-penetrating peptides (CPPs) are promising vehicles for intracellular delivery of different
cargoes. Although various CPPs are designed for targeted delivery of nanomedicines and …

Activatable cell-penetrating peptides: 15 years of research

H de Jong, KM Bonger, DWPM Löwik - RSC chemical biology, 2020 - pubs.rsc.org
An important hurdle for the intracellular delivery of large cargo is the cellular membrane,
which protects the cell from exogenous substances. Cell-penetrating peptides (CPPs) can …

Photoactive nanocarriers for controlled delivery

Q **ong, Y Lim, D Li, K Pu, L Liang… - Advanced Functional …, 2020 - Wiley Online Library
Photoactive nanocarriers have emerged as robust and minimally invasive systems for the on‐
demand delivery of active payloads. The easy manipulation offered by light irradiation as an …

Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5-exo-Dig …

J Chaud, C Morville, F Bolze, D Garnier… - Organic …, 2021 - ACS Publications
We herein report the design, synthesis, and photophysical characterization of extended and
rigid coumarinyl derivatives showing large two-photon sensitivities (δaΦu≤ 125 GM) at 740 …

[HTML][HTML] Design, synthesis, and utility of defined molecular scaffolds

D Sato, Z Wu, H Fujita, JS Lindsey - Organics, 2021 - mdpi.com
A growing theme in chemistry is the joining of multiple organic molecular building blocks to
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …

Cell-penetrating peptide-mediated biomolecule transportation in artificial lipid vesicles and living cells

A Miwa, K Kamiya - Molecules, 2024 - pmc.ncbi.nlm.nih.gov
Signal transduction and homeostasis are regulated by complex protein interactions in the
intracellular environment. Therefore, the transportation of impermeable macromolecules …

Advances in cell penetrating peptides and their functionalization of polymeric nanoplatforms for drug delivery

Y Tian, S Zhou - Wiley Interdisciplinary Reviews: Nanomedicine …, 2021 - Wiley Online Library
Cell penetrating peptides (CPPs), known as protein translocation domains, have emerged
as efficient molecular transporters to overcome biological barriers and deliver cell …