Venous leg ulcers (VLUs) are one of the most common ulcers of the lower extremity. VLU
affects many individuals worldwide, could pose a significant socioeconomic burden to the …

Chronic leg ulcers affect 1–2% of the general population and are related to increased
morbidity and health costs. Staphylococcus aureus and Pseudomonas aeruginosa are the …

1. Diabetic chronic wounds, mainly foot ulcers, constitute one of the most common
complications of poorly managed diabetes mellitus. The most typical reasons are insufficient …

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving
the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic …

Diabetic wounds are recalcitrant to healing. However, the mechanism causing this
dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) …

Objective: In the past 20 years, research and clinical trials on the healing process of chronic
wounds have highlighted the key role of the family of enzymes called matrix …

Cutaneous wound healing is a complex mechanism with multiple processes orchestrating
harmoniously for structural and functional restoration of the damaged tissue. Chronic non …

The integration of several cellular responses initiates the process of wound healing. Matrix
Metalloproteinases (MMPs) play an integral role in wound healing. Their main function is …

Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations
of the veins of lower limbs causing a wide range of symptoms and signs with a high …

One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the
lower limbs. There are many etiological environmental factors influencing the development …