Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical
roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway …

MicroRNAs (miRNAs) are small, yet profoundly influential, non-coding RNAs that base-pair
with mRNAs to induce RNA silencing. Although the basic principles of miRNA biogenesis …

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome, caused by
genetic mutations that principally affect telomere biology. Approximately 35% of cases …

Competing exonucleases that promote 3′ end maturation or degradation direct quality
control of small non-coding RNAs, but how these enzymes distinguish normal from aberrant …

In this work, the orderly aggregated catalytic hairpin assembly (OA-CHA) was developed for
synchronous ultrasensitive detection and high-efficiency colocalization imaging of dual …

The levels of non-coding RNAs (ncRNAs) are regulated by transcription, RNA processing,
and RNA degradation pathways. One mechanism for the degradation of ncRNAs involves …

The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …

Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms.
However, the mechanism of HSC regulation is intricate. Studies have shown that there are …