Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract that might lead
to progressive bowel damage and disability. The exact cause of Crohn's disease is …

Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of
immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and …

Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn's disease [CD]. Methods We …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
chronic, progressive, immune-mediated diseases of adults and children that have no cure …

Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aimed to
provide a consensus statement regarding the clinical utility of TDM for biologics in …

Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …

Crohn's disease [CD] is a chronic inflammatory bowel disease [IBD] that can result in
progressive bowel damage and disability. 1 CD can affect individuals of any age, from …

Background The combination of infliximab and immunosuppressant therapy is a standard
management strategy for patients with Crohn's disease. Concerns regarding the implications …

Background We sought to report the effectiveness of infliximab and adalimumab over the
first 3 years of treatment and to define the factors that predict anti-TNF treatment failure and …

Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimising the use of
biologics, and in particular anti-tumour necrosis factor (anti-TNF) therapy, in inflammatory …